Cortical Dynamics of 3-D Surface Perception: Binocular and Half-Occluded Scenic Images

Previous models of stereopsis have concentrated on the task of binocularly matching left and right eye primitives uniquely. A disparity smoothness constraint is often invoked to limit the number of possible matches. These approaches neglect the fact that surface discontinuities are both abundant in natural everyday scenes, and provide a useful cue for scene segmentation. da Vinci stereopsis refers to the more general problem of dealing with surface discontinuities and their associated unmatched monocular regions within binocular scenes. This study develops a mathematical realization of a neural network theory of biological vision, called FACADE Theory, that shows how early cortical stereopsis processes are related to later cortical processes of 3-D surface representation. The mathematical model demonstrates through computer simulation how the visual cortex may generate 3-D boundary segmentations and use them to control filling-in of 3-D surface properties in response to visual scenes. Model mechanisms correctly match disparate binocular regions while filling-in monocular regions with the correct depth within a binocularly viewed scene. This achievement required introduction of a new multiscale binocular filter for stereo matching which clarifies how cortical complex cells match image contours of like contrast polarity, while pooling signals from opposite contrast polarities. Competitive interactions among filter cells suggest how false binocular matches and unmatched monocular cues, which contain eye-of-origin information, arc automatically handled across multiple spatial scales. This network also helps to explain data concerning context-sensitive binocular matching. Pooling of signals from even-symmetric and odd-symmctric simple cells at complex cells helps to eliminate spurious activity peaks in matchable signals. Later stages of cortical processing by the blob and interblob streams, including refined concepts of cooperative boundary grouping and reciprocal stream interactions between boundary and surface representations, arc modeled to provide a complete simulation of the da Vinci stereopsis percept.Office of Naval Research (N00014-95-I-0409, N00014-85-1-0657, N00014-92-J-4015, N00014-91-J-4100); Airforce Office of Scientific Research (90-0175); National Science Foundation (IRI-90-00530); The James S. McDonnell Foundation (94-40

Cortical Computation of Stereo Disparity

Our ability to see the world in depth is a major accomplishment of the brain. Previous models of how positionally disparate cues to the two eyes are binocularly matched limit possible matches by invoking uniqueness and continuity constraints. These approaches cannot explain data wherein uniqueness fails and changes in contrast alter depth percepts, or where surface discontinuities cause surfaces to be seen in depth although they are registered by only one eye (da Vinci stereopsis). A new stereopsis model explains these depth percepts by proposing how cortical complex cells binocularly filter their inputs and how monocular and binocular complex cells compete to determine the winning depth signals.Defense Advanced Research Projects Agency (N00014-92-J-4015); Air Force Office of Scientific Research (90-0175); Office of Naval Research (N00014-91-J-4100); James S. McDonnell Foundation (94-40); Defense Advanced Research Projects Agency and the Office of Naval Research (N00014-95-1-0409, N00014-95-1-0657

Embedding Service Logic into Business Model Design: The Case of Predictive Maintenance for Industry 4.0

Diffusion of new technology can be approached as a good marriage between business model innovation and technological innovation. With maturing and converging technological innovations ranging from Internet-of-Things, Artificial Intelligence, Blockchain to digital platforms comes a fundamental shift in how companies can do business and what can be offered. They enable greenfield services (i.e. services not pre-existing), including servitization of existing products to compete. Whilst businesses are experimenting with services for emerging domains like industry 4.0, research embedding service logic in business model design for delivering and diffusing greenfield services is nascent. Using a Design Science approach, this paper contributes a method (SL-BMD) for designing service logic embedded business models that forefronts how to incorporate the customer’s perspective. We instantiate and evaluate SL-BMD by charting the experimental journey of a Predictive Maintenance offering for manufacturing settings, and highlight implementation considerations for SL-BMD and the experimental case chosen

Four projection streams from primate V1 to the cytochrome oxidase stripes of V2

In the primate visual system, areas V1 and V2 distribute information they receive from the retina to all higher cortical areas, sorting this information into dorsal and ventral streams. Therefore, knowledge of the organization of projections between V1 and V2 is crucial to understand how the cortex processes visual information. In primates, parallel output pathways from V1 project to distinct V2 stripes. The traditional tripartite division of V1-to-V2 projections was recently replaced by a bipartite scheme, in which thin stripes receive V1 inputs from blob columns, and thick and pale stripes receive common input from interblob columns. Here, we demonstrate that thick and pale stripes, instead, receive spatially segregated V1 inputs and that the interblob is partitioned into two compartments: the middle of the interblob projecting to pale stripes and the blob/interblob border region projecting to thick stripes. Double-labeling experiments further demonstrate that V1 cells project to either thick or pale stripes, but rarely to both. We also find laminar specialization of V1 outputs, with layer 4B contributing projections mainly to thick stripes, and no projections to one set of pale stripes. These laminar differences suggest different contribution of magno, parvo, and konio inputs to each V1 output pathway. These results provide a new foundation for parallel processing models of the visual system by demonstrating four V1-to-V2 pathways: blob columns-to-thin stripes, blob/interblob border columns-to-thick stripes, interblob columns-to-pale(lateral) stripes, layer 2/3– 4A interblobs-to-pale(medial) stripes

Kinetic and thermodynamic evaluation of phosphate ions binding onto sevelamer hydrochloride

Sevelamer hydrochloride is the first non-aluminium, non-calcium-based phosphate binder developed for the management of hyperphosphatemia in end stage renal diseases. It is a synthetic ion-exchange polymer which binds and removes phosphate ions due to the high content of cationic charge associated with protonated amine groups on the polymer matrix. This is the first in-depth study investigating phosphate removal in vitro from aqueous solutions using commercially available sevelamer hydrochloride at physiological conditions of phosphate level, pH and temperature. The kinetic and thermodynamic parameters of phosphate binding onto the sevelamer hydrochloride particles were evaluated in order to define the binding process. A series of kinetic studies were carried out in order to delineate the effect of initial phosphate concentration, absorbent dose and temperature on the rate of binding. The results were analysed using three kinetic models with the best-fit of the experimental data obtained using a pseudo-second order model. Thermodynamic parameters provide in-depth information on inherent energetic changes that are associated with binding. Free energy DG�, enthalpy DH�, and entropy DS� changes were calculated in this study in order to assess the relationship of these parameters to polymer morphology. The binding reaction was found to be a spontaneous endothermic process with increasing entropy at the solid–liquid interface

On the reflection of magnon bound states

We investigate the reflection of two-particle bound states of a free open string in the light-cone AdS_5 x S^5 string sigma model, for large angular momentum J=J_56 and ending on a D7 brane which wraps the entire AdS_5 and a maximal S^3 of S^5. We use the superspace formalism to analyse fundamental and two-particle bound states in the cases of supersymmetry-preserving and broken-supersymmetry boundaries. We find the boundary S-matrices corresponding to bound states both in the bulk and on the boundary.Comment: 35 pages, v2: few typos and ref corrected, accepted for publication in JHE

Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial

BackgroundAnterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients with a non-acute ACL injury and persistent symptoms of instability.MethodsWe did a pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units in the UK. Patients with symptomatic knee problems (instability) consistent with an ACL injury were eligible. We excluded patients with meniscal pathology with characteristics that indicate immediate surgery. Patients were randomly assigned (1:1) by computer to either surgery (reconstruction) or rehabilitation (physiotherapy but with subsequent reconstruction permitted if instability persisted after treatment), stratified by site and baseline Knee Injury and Osteoarthritis Outcome Score—4 domain version (KOOS4). This management design represented normal practice. The primary outcome was KOOS4 at 18 months after randomisation. The principal analyses were intention-to-treat based, with KOOS4 results analysed using linear regression. This trial is registered with ISRCTN, ISRCTN10110685, and ClinicalTrials.gov, NCT02980367.FindingsBetween Feb 1, 2017, and April 12, 2020, we recruited 316 patients. 156 (49%) participants were randomly assigned to the surgical reconstruction group and 160 (51%) to the rehabilitation group. Mean KOOS4 at 18 months was 73·0 (SD 18·3) in the surgical group and 64·6 (21·6) in the rehabilitation group. The adjusted mean difference was 7·9 (95% CI 2·5–13·2; p=0·0053) in favour of surgical management. 65 (41%) of 160 patients allocated to rehabilitation underwent subsequent surgery according to protocol within 18 months. 43 (28%) of 156 patients allocated to surgery did not receive their allocated treatment. We found no differences between groups in the proportion of intervention-related complications.InterpretationSurgical reconstruction as a management strategy for patients with non-acute ACL injury with persistent symptoms of instability was clinically superior and more cost-effective in comparison with rehabilitation management